Hankerd K, McDonough KE, Wang J, Tang SJ, Chung JM, La JH (2022) Postinjury stimulation triggers a transition to nociplastic pain in mice. Pain 163(3):461-473. doi: 10.1097/j.pain.0000000000002366 PMID: 34285154
Objective: To facilitate studies on the underlying mechanisms of nociplastic pain, authors developed a mouse model in which postinjury thermal stimulation prolongs capsaicin (ie, experimental injury)-induced transient mechanical hypersensitivity outside of the injury area.
Summary: Results demonstrate that postinjury stimulation of the injured area can trigger the transition from transient pain to nociplastic pain more readily in females, and sex-dependent mechanisms maintain the nociplastic pain state.
Usage: A single intrathecal injection of unconjugated saporin (PR-01) or Mac-1-saporin (IT-06, 8.85 μM, 5 μL).
Related Products: Mac-1-SAP mouse/human (Cat. #IT-06), Saporin (Cat. #PR-01)