McLeod CM, Son S, Haque MN, Garrett AM (2025) Reduced neuronal self-avoidance in mouse starburst amacrine cells with only one Pcdhg isoform. bioRxiv 2025.05.29.656828. doi: 10.1101/2025.05.29.656828
Objective: To determine whether the γC4 isoform of the protocadherin-γ (Pcdhg) gene cluster is sufficient to mediate neuronal self-avoidance in starburst amacrine cells (SACs) in the mouse retina.
Summary: While deletion of γC4 or γC5 alone did not impair SAC self-avoidance, mice expressing only γC4 exhibited significant failures in dendritic self-avoidance that were not fully rescued by transgenic overexpression. These findings suggest γC4 is specialized for neuronal survival but insufficient to support self-avoidance on its own.
Usage: Melanopsin (OPN4) was detected using Anti-Melanopsin (AB-N38) at a 1:2000 dilution to label intrinsically photosensitive retinal ganglion cells (ipRGCs) for analysis of retinal cell spacing and mosaic organization.
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)