Ben-David U, Nudel N, Benvenisty N (2013) Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells. Nat Commun 4:1992. doi: 10.1038/ncomms2992 PMID: 23778593
Objective: To identify a pluripotent cell specific surface marker and develop strategies to selectively eliminate tumorigenic human pluripotent stem cells (hPSCs) from mixed cell populations.
Summary: Claudin-6 (CLDN-6) was identified as a specific surface marker of hPSCs. Targeted elimination using CLDN-6 immunotoxins or sorting, effectively reduced teratoma formation, improving the safety of stem cell–based therapies.
Usage: Fab-ZAP Mouse (IT-48) and a primary anti-CLDN-6 antibody was applied at various concentrations to selectively eliminate CLDN-6–positive hPSCs.
Related Products: Fab-ZAP mouse (Cat. #IT-48)