Kozlova E, Lam A, Alam S, Shum J, Denys M, Berdasco C, de-Lartigue G, Curras-Collazo M (2025) Do CCKA receptor containing vagal afferent neurons mediate gut-brain inflammatory signals?. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.2035
Objective: To investigate whether CCKA receptor, containing vagal afferent neurons (VANs), mediate gut-brain inflammatory signaling and contribute to the systemic immune response following an LPS challenge.
Summary: This abstract reports that ablation of CCKAR+ VANs via CCK-SAP reduced LPS-induced IL-6 levels and brain c-Fos expression, indicating a blunted inflammatory response. These findings support the role of CCKAR+ VANs in gut-brain immune signaling and their potential as therapeutic targets.
Usage: CCK-SAP (IT-31) was bilaterally injected into the nodose ganglia (250 nL, 250 ng/μL) to ablate CCKA receptor–expressing vagal afferents.
Related Products: CCK-SAP (Cat. #IT-31)