Schaible HG, König C, Ebersberger A (2024) Spinal pain processing in arthritis: Neuron and glia (inter)actions. J Neurochem 168(11):3644-3662. doi: 10.1111/jnc.15742 PMID: 36520021
Objective: To address the mechanisms of spinal sensitization evoked by arthritis.
Summary: Neutralization of spinal cytokines by intrathecal interventions attenuates mechanical hyperalgesia. This effect may in part result from local suppression of spinal sensitization and in part from efferent effects which attenuate the inflammatory process in the joint. In summary, arthritis evokes significant spinal hyperexcitability which is likely to contribute to the phenotype of arthritis pain in patients
Usage: Selective microglia destruction with the immunotoxin saporin conjugated to Mac1 antibody (Mac-1-SAP Cat #IT-06, recognizes Mac1 receptor on microglia) attenuated the development of hyperalgesia.
Related Products: Mac-1-SAP mouse/human (Cat. #IT-06)