Yang Q, Liu L, He F, Zhao W, Chen Z, Wu X, Rao B, Lin X, Mao F, Qu J, Zhang J (2024) Retinal ganglion cell type-specific expression of synuclein family members revealed by scRNA-sequencing. Int J Med Sci 21(8):1472-1490. doi: 10.7150/ijms.95598
Objective: To analyze the single-cell transcriptome in healthy and injured retinas to investigate their expression patterns and roles.
Summary: The study revealed that Snca expression varies across RGC subtypes, while Sncb and Sncg are uniformly expressed. Following traumatic axonal injury, Snca, Sncb, and Sncg levels decreased. The proportions of α-Syn-positive RGCs and ipRGCs remained unchanged, with notable changes in Ptn-Ncl and NCAM signaling pathways preceding cell death.
Usage: Immunofluorescence staining (AB-N39) (1:3000).
Related Products: Melanopsin Rabbit Polyclonal, affinity-purified (Cat. #AB-N39)