Contreras E, Liang C, Mahoney HL, Javier JL, Luce ML, Labastida Medina K, Bozza T, Schmidt TM (2024) Flp-recombinase mouse line for genetic manipulation of ipRGCs. bioRxiv doi: 10.1101/2024.05.06.592761 PMID: 38766000
Objective: To report the generation and characterization of a new mouse line (Opn4FlpO), in which FlpO is expressed from the Opn4 locus, to manipulate the melanopsin-expressing, intrinsically photosensitive retinal ganglion cells.
Summary: The Opn4FlpO mouse line drives Flp-recombinase expression specifically within ipRGCs, with robust recombination in M1-M3 ipRGC subtypes. This model is a valuable tool for investigating these retinal cells’ physiological and behavioral roles.
Usage: Retinal histology (1:2000 dilution) (AB-N38).
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)