Akmese C, Sevinc C, Halim S, Unal G (2023) Differential role of GABaergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping. Prog Neuropsychopharmacol Biol Psychiatry 125:110760. doi: 10.1016/j.pnpbp.2023.110760 PMID: 37031946
Objective: To investigate the role of the ventral pallidum (VP) in regulating the brain’s reward circuitry in appetitive behaviors and emotional regulation through GABAergic and Cholinergic lesions.
Summary: Using GAT1-SAP (GABAergic) or 192-IgG-SAP (cholinergic), injections were made into the VP to eliminate neurons in rats. These lesioned rats were subjected to fear conditioning tests, and it was shown that the VP may contribute to emotion regulation by suppressing active coping and promoting species-specific passive behaviors.
Usage: Bilateral injections of GAT1-SAP (325 ng/μl, 0.5 μl volume, 0.1 μl/min), 192-IgG-SAP (500 ng/μl in PBS, 0.5 μl volume, 0.1μl/min), or PBS (0.5 μl volume, 0.1 μl/min) into the Ventral Pallidum.
Related Products: GAT1-SAP (Cat. #IT-32), 192-IgG-SAP (Cat. #IT-01)