Meng XT, Song SY, Li Y, Peng S, Zhang LC (2024) Activation of alpha 2 adrenergic receptor of cerebrospinal fluid-contacting nucleus alleviates acute incision pain behavior in rats. Research Square doi: 10.21203/rs.3.rs-4258857/v1
Objective: To study the effects of Dexmedetomidine (DEX) on pain modulation.
Summary: Dexmedetomidine is an alpha 2-adrenergic receptor agonist with sedative, analgesic, and anti-anxiety effects. DEX was analyzed for its effects using a pain neuron knockout model of rats created by ablation of cerebrospinal fluid contacting neurons in the lateral ventricles of rats. DEX inhibited the pain behavior of rats in a dose-dependent manner, and the analgesic effect of DEX was significantly attenuated in CSF-contacting nucleus “knockout” rats.
Usage: CTB-SAP [IT-14] (0.5 µg in 3 µL) was injected into the lateral ventricles (L.V.) of rats over 10 minutes.
Related Products: CTB-SAP (Cat. #IT-14)