Sonokawa T, Obi N, Usuda J, Sudo Y, Hamakubo T (2023) Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer 14(7):645-653. doi: 10.1111/1759-7714.14776 PMID: 36655546
Objective: Using a photo-sensitizer and red light to release Cetuximab-saporin to target cancer.
Summary: Photodynamic therapy is a non-invasive cancer treatment using a photo-sensitizer and laser irradiation to control the delivery of the chemotherapy agent. Streptavidin-ZAP mixed with biotinylated Cetuximab and a photo-sensitizer (mono-L-aspartyl chlorin e6) is used as an anti-cancer immunotoxin. In vitro analysis demonstrated that the novel photodynamic therapy method enhanced the cytotoxicity of Cetuximabe-SAP.
Usage: Streptavidin-ZAP (IT-27) mixed with biotinylated Cetuximab was used in vitro in A431, A549, and MCF7 cells.
Related Products: Streptavidin-ZAP (Cat. #IT-27)