Cutuli D, Landolfo E, Nobili A, De Bartolo P, Sacchetti S, Chirico D, Marini F, Pieroni L, Ronci M, D’Amelio M, D’Amato FR, Farioli-Vecchioli S, Petrosini L (2020) Behavioral, neuromorphological, and neurobiochemical effects induced by omega-3 fatty acids following basal forebrain cholinergic depletion in aged mice. Alzheimers Res Ther 12(1):150. doi: 10.1186/s13195-020-00705-3 PMID: 33198763
Objective: To investigate the action of omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on behavioral performances and hippocampal neurogenesis, volume, and astrogliosis in aged mice subjected to a selective depletion of basal forebrain cholinergic neurons.
Summary: The n-3 PUFA treatment regulated the anxiety alterations and reverted the novelty recognition memory impairment induced by the cholinergic depletion in aged mice. Moreover, n-3 PUFA preserved hippocampal volume, enhanced neurogenesis in the dentate gyrus, and reduced astrogliosis in the hippocampus. Brain levels of n-3 PUFA were positively related to mnesic abilities.
Usage: Intracerebroventricular (i.c.v.) injection of mu-p75-saporin in each lateral ventricle (total dosage: 0.6μg/mouse)
Related Products: mu p75-SAP (Cat. #IT-16)