Distinct behavioral consequences of short-term and prolonged GABAergic depletion in prefrontal cortex and dorsal hippocampus

Reichel JM, Nissel S, Rogel-Salazar G, Mederer A, Käfer K, Bedenk BT, Martens H, Anders R, Grosche J, Michalski D, Härtig W, Wotjak CT (2015) Distinct behavioral consequences of short-term and prolonged GABAergic depletion in prefrontal cortex and dorsal hippocampus. Front Behav Neurosci 8:452. doi: 10.3389/fnbeh.2014.00452 PMID: 25628548

Objective: To study the effects of GABAergic interneurons on exploratory and cognitive behavior and their involvement in schizophrenia-related symptoms.

Summary: The authors demonstrated that GABAergic lesions result in distinct behavioral phenotypes specific to the target site and modulated by incubation time. They were able to simulate a pathological disease state and the consequences of prolonged GABAergic depletion.

Related Products: Anti-vGAT-SAP (Cat. #IT-71)

See Also:

• Antonucci F et al. Cracking down on inhibition: Selective removal of GABAergic interneurons from hippocampal networks. J Neurosci 32(6):1989-2001, 2012.