Cutuli D, Landolfo E, Decandia D, Nobili A, Viscomi MT, La Barbera L, Sacchetti S, De Bartolo P, Curci A, D’Amelio M, Farioli-Vecchioli S, Petrosini L (2020) Neuroprotective role of dietary supplementation with omega-3 fatty acids in the presence of basal forebrain cholinergic neurons degeneration in aged mice. Int J Mol Sci 21(5):1741. doi: 10.3390/ijms21051741 PMID: 32143275
Objective: Examine the neuroprotective effects of omega-3 polyunsaturated fatty acids in an Alzheimer’s model of aged mice.
Summary: Aged mice were fed omega-3 polyunsaturated fatty acids (n-3 PUFA) or a caloric-equivalent source of fat without n-3 PUFA. Afterward, mice were subjected to lesioning of the cholinergic system with mu p-75-SAP (Cat. IT-16) and assessed for dementia-like symptoms. Mice fed with n-3 PUFA performed better on memory retention tasks and had more exploratory behaviors.
Usage: Intracerebroventricular (i.c.v.) injections of mu-p75-saporin (IT-16); total dosage 0.6 μg/mouse.
Related Products: mu p75-SAP (Cat. #IT-16)