Liu H, Xue Y, Chen L (2022) Angiotensin II increases the firing activity of pallidal neurons and participates in motor control in rats. Metab Brain Dis 38:573-587. doi: 10.1007/s11011-022-01127-w PMID: 36454502
Objective: To investigate the functions of angiotensin II (Ang II)/angiotensin subtype 1 receptor (AT1R) on the globus pallidus neurons of both normal and Parkinsonian rats.
Summary: The authors conclude that pallidal Ang II/AT1R alleviated Parkinsonian motor deficits by activating globus pallidus neurons. This provides a rationale for further investigations into the potential of Ang II for treating motor disorders originating from the basal ganglia.
Usage: Coronal Sections (40 μm) containing the globus pallidus were blocked with 5% BSA and 0.3% Triton X-100 in PBS for 45 min and subsequently incubated with AT1R antibody (AB-N27AP) for 48 h at 4°.
Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)