Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms

Krieger JP (2020) Intestinal glucagon-like peptide-1 effects on food intake: Physiological relevance and emerging mechanisms. Peptides 131:170342. doi: 10.1016/j.peptides.2020.170342 PMID: 32522585

Objective: Review of findings of GLP-1 involvement in obesity.

Summary: The most selective method of gastrointestinal vagal deafferentation to date used CCK-SAP injected into the nodose ganglia which blunts the anorexigenic effect of IP GLP-1 administration.

Related Products: CCK-SAP (Cat. #IT-31)

See Also:

• Diepenbroek C et al. Validation and characterization of a novel method for selective vagal deafferentation of the gut. Am J Physiol Gastrointest Liver Physiol 313:G342-G352, 2017.