Souza-Silva E, Stein T, Mascarin LZ, Dornelles FN, Bicca MA, Tonussi CR (2020) Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model. Brain Res 1735:146757. doi: 10.1016/j.brainres.2020.146757 PMID: 32135147
Objective: To investigate the participation of spinal NPY in the antinociceptive effect produced by 2-pyridylethylamine (2-PEA).
Summary: These data support the idea that antinociception induced by H1R agonists in the knee-joint of rats may be mediated by the spinal release of NPY, and this peptide seems to be acting via Y1R.
Usage: IT pretreatment with NPY-SAP (750 ng) reduced immunoblotting for Y1R in spinal cord homogenates.
Related Products: NPY-SAP (Cat. #IT-28)