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Effects of propofol on sleep architecture and sleep-wake systems in rats

Yue XF, Wang AZ, Hou YP, Fan K (2021) Effects of propofol on sleep architecture and sleep-wake systems in rats. Behav Brain Res 411:113380. doi: 10.1016/j.bbr.2021.113380

Objective: To characterize the effects of propofol on the profile of sleep–wake states and cortical electroencephalogram (EEG) power spectral density in rats following intraperitoneal injection.

Summary: The high dose of propofol produced high-quality sleep by increasing SWS2, whereas the medium dose produced fragmented and low-quality sleep by disrupting the continuity of wakefulness.

Usage: Bilateral injection of Orexin-SAP (92 and 184 ng/ml, 0.25 ml in the ventral tegmental area and 0.5 ml in the substantia nigra) of rats induced insomnia, as well as hyperactivity and stereotypic movements

Related Products: Orexin-B-SAP (Cat. #IT-20)

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