Gerashchenko D, Blanco-Centurion CA, Miller JD, Shiromani PJ (2006) Insomnia following hypocretin2-saporin lesions of the substantia nigra. Neuroscience 137(1):29-36. doi: 10.1016/j.neuroscience.2005.08.088
Objective: To investigate which regions of major arousal areas might be responsible for the changes in sleep-wake architecture
Summary: It is known that orexin (also known as hypocretin) is involved in waking. The results suggest that motor activity is under inhibitory control of the substantia nigra.
Usage: Bilateral injection of Orexin-SAP (92 and 184 ng/ml, 0.25 ml in the ventral tegmental area and 0.5 ml in the substantia nigra) of rats induced insomnia, as well as hyperactivity and stereotypic movements.
Related Products: Orexin-B-SAP (Cat. #IT-20)