Probing transferrin receptor overexpression in gastric cancer mice models

Lodhi MS, Khan MT, Bukhari SMH, Sabir SH, Samra ZQ, Butt H, Akram MS (2021) Probing transferrin receptor overexpression in gastric cancer mice models. ACS Omega 6(44):29893-29904. doi: 10.1021/acsomega.1c04382 PMID: 34778662

Objective: To investigate the role of the transferrin receptor, a glycoprotein receptor that is expressed many-folds on rapidly growing cells due to the greater demand of iron, in gastric cancer.

Summary: A mouse model of gastric cancer has the potential to be used in the future to study the therapeutic effects of cancer medicines, and overexpression of transferrin receptors could be identified through the designed probe to be used as diagnostics.

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See Also:

• Daniels TR et al. Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Mol Cancer Ther 6:2995-3008, 2007.