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Centrally projecting edinger-westphal nucleus in the control of sympathetic outflow and energy homeostasis

Cano G, Hernan SL, Sved AF (2021) Centrally projecting edinger-westphal nucleus in the control of sympathetic outflow and energy homeostasis. Brain Sci 11(8):1005. doi: 10.3390/brainsci11081005

Objective: To test the hypothesis that Edinger-Westphal nucleus (EWcp) integrates multimodal signals (stress, thermal, metabolic, endocrine, etc.) and modulates the sympathetic output simultaneously to multiple effector organs to maintain energy homeostasis under different conditions that require adjustments of energy demands.

Summary: Besides its role in feeding/metabolic control and addiction, EWcp is involved in several important functions that are ultimately related to different aspects of stress responses, as well as stress coping and adaptation.

See: Xu L et al. Peptidergic Edinger-Westphal neurons and the energy-dependent stress response. Gen Comp Endocrinol 177(3):296-304, 2012.

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