Berthoud HR, Morrison CD, Ackroff K, Sclafani A (2021) Learning of food preferences: mechanisms and implications for obesity & metabolic diseases. Int J Obes (Lond) 45(10):2156-2168. doi: 10.1038/s41366-021-00894-3
Objective: This review focuses on postoral nutrient sensing and signaling as an essential part of the reward system that shapes preferences for the associated flavors of foods.
Summary: There is a critical role for the vagal gut-to-brain axis in motivation and reward. An implication for obesity treatment is that bariatric surgery may alter vagal function.
Usage: Han et al. injected 0.5 µl of CCK-SAP (250 ng/µl) into the R-NG of VGlut2-ires-Cre mice.
See: Han W et al. A Neural Circuit for Gut-Induced Reward. Cell 175:665-678, 2018.
Related Products: CCK-SAP (Cat. #IT-31)