Li F, Jiang H, Shen X, Yang W, Guo C, Wang Z, Xiao M, Cui L, Luo W, Kim BS, Chen Z, Huang AJW, Liu Q (2021) Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem. Cell 184(14):3762-3773.e10. doi: 10.1016/j.cell.2021.05.017
Objective: To test the hypothesis that a neuronal population postsynaptic to nasal sensory neurons mediates sneezing.
Summary: Chemical activation of neuromedin B (NMB)-sensitive neurons elicits action potentials in caudal ventral respiratory group (cVRG) neurons and leads to sneezing behavior. This study delineates a peptidergic pathway mediating sneezing, providing molecular insights into the sneezing reflex arc.
Usage: Microinjection of NMB-saporin into the sneeze-evoking region abolished the sneezing responses to capsaicin and histamine.
Related Products: NMB-SAP (Cat. #IT-70)