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Utilization of pectoralis minor accessory inspiratory muscles in a rodent model of respiratory motor neuron loss

Borkowski L, Nichols N (2021) Utilization of pectoralis minor accessory inspiratory muscles in a rodent model of respiratory motor neuron loss. The FASEB Journal 35 (S1). doi: 10.1096/fasebj.2021.35.S1.01843

Objective: To develop a model of selective respiratory motor neuron death to study how breathing is impacted and advance targeted therapeutic interventions.

Summary: Prior to ventilatory failure, patients can maintain breathing potentially via recruitment of accessory inspiratory muscles (e.g., pectoralis minor). The data suggest that the pectoralis minor muscles have an independent motor pool that can become recruited to assist in maintaining eupnea (normal respiration).

Usage: Adult male rats received bilateral CTB-SAP or control (CTB unconjugated to SAP) intrapleurally.

Related Products: CTB-SAP (Cat. #IT-14)