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Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data

Nazmuddin M, Philippens IHCHM, van Laar T (2021) Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data. Sci Rep 11(1):11751. doi: 10.1038/s41598-021-91391-0

Objective: Review the design of stimulation experiments on the nucleus basalis of Meynert (NBM) and its effects on behavioral and neurophysiological aspects.

Summary: Deep brain stimulation (DBS) of the NBM (nucleus basalis of Meynert) in animal studies and the effects on behavioral and neurophysiological aspects are systematically reviewed. Translation of these outcomes to current clinical practice is hampered by the fact that mainly animals with an intact NBM were used, and most animals were stimulated unilaterally. Lee et al. (2016) addressed both of these issues using 192-IgG-SAP to lesion the NBM, which was stimulated thereafter.

Usage: Lee et al. lesioned the basal forebrain of rats through bilateral injections totaling 5 μg of 192-IgG-SAP into the lateral ventricle.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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