Medial parabrachial nucleus is essential in controlling wakefulness in rats

Xu Q, Wang DR, Dong H, Chen L, Lu J, Lazarus M, Cherasse Y, Chen GH, Qu WM, Huang ZL (2021) Medial parabrachial nucleus is essential in controlling wakefulness in rats. Front Neurosci 15:645877. doi: 10.3389/fnins.2021.645877

Summary: Lesions of the LC with 192-IgG-SAP have no significant effect on wakefulness in rats (Blanco-Centurion et al.). Only the Orexin-SAP lesion involved in the MPB region resulted in the dramatic decrease of wakefulness in rats (Fuller et al.).

Related Products: 192-IgG-SAP (Cat. #IT-01), Orexin-B-SAP (Cat. #IT-20)

See Also:

• Blanco-Centurion C et al. Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. J Neurosci 27:14041-14048, 2007.
• Fuller P et al. Reassessment of the structural basis of the ascending arousal system. J Comp Neurol 519(5):933-956, 2011.