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Neuroimmune interactions and osteoarthritis pain: focus on macrophages

Geraghty T, Winter DR, Miller RJ, Miller RE, Malfait AM (2021) Neuroimmune interactions and osteoarthritis pain: focus on macrophages. Pain Rep 6(1):e892. doi: 10.1097/PR9.0000000000000892

Summary: The contribution of macrophages to osteoarthritis (OA) joint damage has garnered much attention in recent years. The authors discuss how macrophages participate in the initiation and maintenance of pain in OA and provide a review of preclinical models of OA.

Usage: Using the rat monoiodoacetate-induced (MIA) model of advanced knee OA, increased microglia were observed in the ipsilateral and contralateral dorsal horn by day 7; specific ablation of spinal microglia through intrathecal injections of Mac-1-SAP (15 mcg per intrathecal injection on days 0, 1, and 2), attenuated mechanical allodynia by days 5 and 7 after MIA.

See: Mousseau M et al. Microglial pannexin-1 channel activation is a spinal determinant of joint pain. Sci Adv 4:1-12, 2018.

Related Products: Mac-1-SAP mouse/human (Cat. #IT-06)