Wrenn CC, Wiley RG (2001) Lack of effect of moderate Purkinje cell loss on working memory. Neuroscience 107(3):433-445. doi: 10.1016/s0306-4522(01)00326-8
Summary: When 192-Saporin (Cat. #IT-01) is injected intracerebroventricularly, some p75-expressing cerebellar Purkinje cells are eliminated along with cholinergic neurons. To verify that the effects of basal forebrain lesions on working memory were not caused by loss of these Purkinje cells the authors compared doses of 1 µg OX7-SAP (Cat. #IT-02) and either 2 µg or 4 µg of 192-Saporin injected into the lateral ventricle. The data show that although similar amounts of Purkinje cells were eliminated by OX7-SAP and the lower dose of 192-Saporin, no working memory deficits resulted. Only the 4-µg dose of 192-Saporin produced working memory deficits, they conclude that this is not due to Purkinje cell loss, but the loss of cholinergic neurons.
Related Products: 192-IgG-SAP (Cat. #IT-01), OX7-SAP (Cat. #IT-02)