Burk JA, Sarter M (2001) Dissociation between the attentional functions mediated via basal forebrain cholinergic and GABAergic neurons. Neuroscience 105(4):899-909. doi: 10.1016/s0306-4522(01)00233-0
Summary: The specificity and efficacy of 192-Saporin (Cat. #IT-01) has allowed the extensive investigation of cortical cholinergic inputs in attentional functions. Little is known about the function of non-cholinergic neurons because of the lack of a specific tool to eliminate these projections. The authors injected 192-Saporin (0.1 µg/0.5 µl bilateral infusions) into rats and compared performance to rats treated with ibotenic acid to eliminate GABAergic neurons in attention performance tasks. While the ibotenic acid lesions were not as specific as those produced by 192-Saporin, the data suggest a role for the basal forebrain GABAergic neurons in attentional functions.
Related Products: 192-IgG-SAP (Cat. #IT-01)