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  4. Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle.

Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle.

Ballmaier M, Casamenti F, Zoli M, Pepeu G, Spano P (2001) Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle. Neuroscience 108(2):299-305. doi: 10.1016/s0306-4522(01)00413-4

Summary: One of the measures for schizophrenia is a deficit in sensorimotor gating (the ability of the brain to filter sensory input to focus on selective stimuli) measured by prepulse inhibition (PPI) of the startle reflex. The authors injected 300 nl of 400 ng/┬Ál 192-Saporin (Cat. #IT-01) into each side of the nucleus basalis magnocellularis (NBM) in rats to examine the effect of NBM cholinergic neuron elimination on the startle reflex. The data show a significant, persistent disruption of the PPI independent of the amplitude of the startle reflex. This suggests the NBM may play an important role in information processing in schizophrenia.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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