Nizari S, Wells JA, Carare RO, Romero IA, Hawkes CA (2021) Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice. Acta Neuropathol Commun 9(1):12. doi: 10.1186/s40478-020-01108-z
Summary: In this report, icv administration of mu p75-SAP resulted in significant death of cholinergic neurons and fibres in the medial septum, cortex and hippocampus of C57BL/6 mice. This study supports the importance of the interrelationship between cholinergic innervation and vascular function in the etiology and/or progression of cerebral amyloid angiopathy (CAA) and suggests that combined endothelial nitric oxide synthase (eNOS)/cholinergic therapies may improve the efficiency of Aβ removal from the brain and reduce its deposition as CAA.
Usage: mu p75-SAP (0.596 μg/μl) was injected into the left and right lateral ventricles.
Related Products: mu p75-SAP (Cat. #IT-16)