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Molecular genetics of kappa opioids in pain and itch sensations

Tseng PY, Hoon MA (2020) Molecular genetics of kappa opioids in pain and itch sensations. Handb Exp Pharmacol . doi: 10.1007/164_2020_397

Summary: The authors review the functions of the kappa opioid receptor (KOR) and its endogenous agonists dynorphins in modulating itch and pain. Nppb-SAP ablation of neurons expressing the Natriuretic olypeptide B receptor greatly reduced itch responses evoked by histamine or by intrathecal administration of Nppb, suggesting that these neurons transmit itch signals from Nppb primary afferents.

See: Mishra SK et al. The cells and circuitry for itch responses in mice. Science 340(6135):968-971, 2013.

Related Products: Nppb-SAP (Cat. #IT-69)