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Tongue and hypoglossal morphology after intralingual cholera toxin B-saporin injection

Lind LA, Lever TE, Nichols NL (2021) Tongue and hypoglossal morphology after intralingual cholera toxin B-saporin injection. Muscle Nerve 63(3):413-420. doi: 10.1002/mus.27131

Objective: To evaluate tongue morphology and ultrastructural changes in hypoglossal neurons and nerve fibers in an inducible rat model of dysphagia.

Summary: Preliminary results indicate this model may have translational application to a variety of neurodegenerative diseases resulting in tongue dysfunction and associated dysphagia.

Usage: Rats assigned to the CTB-SAP group (n = 10) received 25 μg CTB-SAP to produce hypoglossal motor neuron death.

Related Products: CTB-SAP (Cat. #IT-14)