Wehner A, Milen A, Albin R, Pierchala B (2016) The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175(WT/HD) mice. Neuroscience 324:297-306. doi: 10.1016/j.neuroscience.2016.02.069
Summary: Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder. It’s characterized by a combination of motor, cognitive, and psychiatric features. Striatal spiny neurons are dependent on brain-derived neurotropic factor for proper function and survival. Studies suggest both the receptors for BDNF, TrkB and the p75 neurotrophin receptor (p75), are improperly regulated in the striata of HD patients and mouse models. The authors investigated the role of p75 in the Q175 knock-in mouse model of HD be examining levels of activation of downstream signaling molecules to determine if p75 represents a promising therapeutic target. Anti-NGFr (mup75) (Cat. #AB-N01AP) was used at a 1:2000 dilution in immunoblotting. The data suggest that p75 signaling plays an early role in augmenting pro-survival signaling in the striatum and that disruption of p75 signaling at a pre-symptomatic age may exacerbate pathologic changes in these knock-in mouse models.
Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)