Murray R, Logan M, Horner K (2015) Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration. Brain Res 1618:286-298. doi: 10.1016/j.brainres.2015.06.012
Summary: Stereotypy is defined as abnormally repetitive motor movements accompanied by an inability to initiate normal adaptive responses. Psychostimulants such as cocaine will often produce these movements. It is thought that stereotypy is related to activation of the patch compartment of the striatum. In order to better understand the function of the patch compartment in stereotypy due to repeated exposure to cocaine, the authors administered bilateral injections of Dermorphin-SAP (Cat. #IT-12) into the rostral striatum. Saporin (Cat. #PR-01) was used as a control.