Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration.

Murray R, Logan M, Horner K (2015) Striatal patch compartment lesions reduce stereotypy following repeated cocaine administration. Brain Res 1618:286-298. doi: 10.1016/j.brainres.2015.06.012 PMID: 26100338

Objective: Investigate the impact of neuron ablation in the striatum on stereotypy, a form of repetitive and uncontrollable behavior, in rats following cocaine administration.

Summary: Stereotypy, characterized by rigid, repetitive behaviors after psychostimulant exposure, is linked to the activation of the patch compartment within the striatum. To clarify the role of these neurons, they were selectively ablated, resulting in a noticeable reduction in the intensity of stereotypy behaviors.

Usage: 2 microliters of Dermorphin-SAP (IT-12) at a concentration of 17 ng/μl were administered bilaterally into the patch compartment of the striatum. Saporin (Cat. #PR-01) was used as a control.

Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12), Saporin (Cat. #PR-01)

See Also:

• Saporin (Cat. #PR-01) was used as a control.