Evaluation of the adverse effects of chronic exposure to donepezil (an acetylcholinesterase inhibitor) in adult zebrafish by behavioral and biochemical assessments.

Audira G, Ngoc Anh NT, Ngoc Hieu BT, Malhotra N, Siregar P, Villalobos O, Villaflores OB, Ger TR, Huang JC, Chen KH, Hsiao CD (2020) Evaluation of the adverse effects of chronic exposure to donepezil (an acetylcholinesterase inhibitor) in adult zebrafish by behavioral and biochemical assessments. Biomolecules 10(9):1340. doi: 10.3390/biom10091340 PMID: 32962160

Objective: The authors use zebrafish to conduct a deeper analysis of the potential adverse effects of DPZ on the short-term memory and behaviors of normal zebrafish by performing multiple behavioral and biochemical assays.

Summary: Chronic waterborne exposure to donepezil (DPZ) can severely induce adverse effects on normal zebrafish in a dose-dependent manner.

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See Also:

• Cutuli D et al. Neuroprotective effects of donepezil against cholinergic depletion. Alzheimers Res Ther 5(5):50, 2013.