Dobryakova YV, Stepanichev MY, Markevich VA, Bolshakov AP (2020) Long-term potentiation in the hippocampal CA3 to CA1 synapses may be induced in vivo by activation of septal cholinergic inputs. Int J Neurosci 23:1-7. doi: 10.1080/00207454.2020.1822834
Objective: To clarify the role of septal input in the development of long-term potentiation (LTP) in this synapse.
Summary: Elimination of septal cholinergic neurons by 192-IgG-SAP abolished LTP development in both experimental series. This suppression of LTP in animals with a cholinergic deficit was not due to loss of hippocampal neurons.
Usage: Rats received intraseptal injections of 192-IgG-SAP (1.5 μg).
Related Products: 192-IgG-SAP (Cat. #IT-01)