Cai L, Gibbs RB, Johnson DA (2012) Recognition of novel objects and their location in rats with selective cholinergic lesion of the medial septum. Neurosci Lett 506(2):261-265. doi: 10.1016/j.neulet.2011.11.019
Summary: This work examined object recognition and object location recognition as specific components of memory. Rats received 0.22 μg of 192-IgG-SAP (Cat. #IT-01) infused into the medial septum followed by testing in novel object recognition (NOR) and object location recognition (OLR) models. Substantial decreases in choline acetyltransferase activity in the hippocampus and frontal cortex produced no difference in NOR but caused a significant impairment in OLR – highlighting the role that septo-hippocampal cholinergic projections play in OLR.
Related Products: 192-IgG-SAP (Cat. #IT-01), Mouse IgG-SAP (Cat. #IT-18)