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Impaired visual search in rats reveals cholinergic contributions to feature binding in visuospatial attention.

Botly LC, De Rosa E (2012) Impaired visual search in rats reveals cholinergic contributions to feature binding in visuospatial attention. Cereb Cortex 22(10):2441-2453. doi: 10.1093/cercor/bhr331

Summary: Previous work established the role of acetylcholine from the nucleus basalis magnocellularis in attentional processing and visuospatial attention. In order to investigate the necessity of cortical cholinergic input for support of feature binding in visuospatial attention the authors administered bilateral intraparenchymal injections of 192-IgG-SAP (Cat. #IT-01, 4 injections, 40 ng per injection). Lesioned animals took longer to locate targets during type-specific search trials, demonstrating that cholinergic input influences feature binding during visuospatial attention tasks.

Related Products: 192-IgG-SAP (Cat. #IT-01), Mouse IgG-SAP (Cat. #IT-18)