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S38. Dissecting the functional heterogeneity of serotonergic systems that regulate fear and panic.

Bernabe C, Caliman I, de Abreu A, Dustrude E, Molosh A, Shekhar A, Johnson P (2019) S38. Dissecting the functional heterogeneity of serotonergic systems that regulate fear and panic. Biol Psychiatry 85(10):S311. doi: 10.1016/j.biopsych.2019.03.789

Objective: To elucidate the role of these serotonergic networks on learned fear and innate panic responses.

Summary: LED excitation or lesioning of PeF projecting 5-HT system respectively attenuated and enhanced panic-associated escape/flight behaviors and cardioexcitation following a 7.5 and 20% CO2 challenge.

Usage: Anti-SERT-SAP was injected into the BLA or PeF to lesion these 5-HT pathways.

Related Products: Anti-SERT-SAP (Cat. #IT-23)