Bernabe C, Caliman I, de Abreu A, Dustrude E, Molosh A, Shekhar A, Johnson P (2019) S38. Dissecting the functional heterogeneity of serotonergic systems that regulate fear and panic. Biol Psychiatry 85(10):S311. doi: 10.1016/j.biopsych.2019.03.789
Objective: To elucidate the role of these serotonergic networks on learned fear and innate panic responses.
Summary: LED excitation or lesioning of PeF projecting 5-HT system respectively attenuated and enhanced panic-associated escape/flight behaviors and cardioexcitation following a 7.5 and 20% CO2 challenge.
Usage: Anti-SERT-SAP was injected into the BLA or PeF to lesion these 5-HT pathways.
Related Products: Anti-SERT-SAP (Cat. #IT-23)