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Brain stem catecholamines circuitry: Activation by alcohol and role in the hypothalamic-pituitary-adrenal response to this drug.

Lee S, Craddock Z, Rivier C (2011) Brain stem catecholamines circuitry: Activation by alcohol and role in the hypothalamic-pituitary-adrenal response to this drug. J Neuroendocrinol 23(6):531-541. doi: 10.1111/j.1365-2826.2011.02131.x

Summary: In this work the authors investigated mechanisms underlying the stimulatory effect of alcohol on the hypothalamic-pituitary-adrenal axis (HPA). One method used was 33-ng injections of anti-DBH-SAP (Cat. #IT-03) into the A2/C2/C3 and A1/C1 regions. The data generated show that catecholamines, especially in the brainstem, regulate the HPA response to alcohol. This regulation utilizes α1-adrenergic receptors. Administration of anti-DBH-SAP to the A1-A2/C1-C3 regions disrupted the catecholaminergic input to the paraventricular nucleus.

Related Products: Anti-DBH-SAP (Cat. #IT-03)