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  4. Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule.

Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule.

Olarte-Sánchez CM, Valencia Torres L, Body S, Cassaday HJ, Bradshaw CM, Szabadi E (2012) Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule. J Psychopharmacol 26(6):871-886. doi: 10.1177/0269881111409607

Summary: It has been suggested that orexigenic neurons in the hypothalamus consist of two anatomically distinct groups. The lateral hypothalamic area group (LHA), which modulates reinforcement mechanisms; and the dorsomedial hypothalamus and perifornical area group involved in regulation of stress and arousal. Rats received bilateral 15 ng injections of orexin-SAP (Cat. #IT-20) into the LHA. Results from a progressive ratio model indicate that the lesioned neurons control the motor component of food-reinforced responding.

Related Products: Orexin-B-SAP (Cat. #IT-20)