Montandon G, Qin W, Liu H, Ren J, Greer JJ, Horner RL (2011) PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. J Neurosci 31(4):1292-1301. doi: 10.1523/JNEUROSCI.4611-10.2011 PMID: 21273414
Summary: In order to identify the neurons involved with respiratory depression due to administration of opioids, some neuro- transmission networks in the preBotzinger complex were locally manipulated. Among various techniques used to analyze the results was immunohistochemistry with anti-NK1r (Cat. #AB-N04). Results show the preBotzinger complex is responsible for suppression of respiratory rate due to opioids.
Related Products: Antibody to NK-1 Receptor (Cat. #AB-N04)