1. Home
  2. Knowledge Base
  3. References
  4. Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium.

Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium.

Girard BM, Malley SE, Vizzard MA (2011) Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium. Am J Physiol Renal Physiol 300(2):F345-55. doi: 10.1152/ajprenal.00515.2010

Summary: Chronic overexpression of nerve growth factor (NGF) in the urinary bladder results in neuronal sprouting, increased voiding frequency, and referred somatic hypersensitivity. The authors investigated several growth factor and receptor responses to chronic overexpression of NGF. A p75 antibody (Cat. #AB-N01) was used to obtain the immunohistochemistry data. The data suggest that changes due to NGF overexpression may be a compensatory attempt to reduce voiding frequency.

Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)