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  4. Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons.

Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons.

Gibbs RB, Chipman AM, Nelson D (2011) Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons. Horm Behav 59(4):503-511. doi: 10.1016/j.yhbeh.2011.01.011

Summary: Among the beneficial effects of estrogen on the brain are improved cognitive performance and prevention of age-related cognitive decline. These positive effects diminish over time following loss of ovarian function. To investigate the role of cholinergic neurons in this process, rats received 96-250 ng of 192-IgG-SAP (Cat. #IT-01) into the medial septal nucleus followed by a cholinergic enhancer and estradiol therapy. The dual therapy had a positive effect on partially lesioned animals, but did not improve the performance of animals with severe lesions.

Related Products: 192-IgG-SAP (Cat. #IT-01)