Antonini V, Marrazzo A, Kleiner G, Coradazzi M, Ronsisvalle S, Prezzavento O, Ronsisvalle G, Leanza G (2011) Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion. J Alzheimers Dis 24(3):569-586. doi: 10.3233/JAD-2011-101794 PMID: 21297260
Summary: Sigma-1 receptor agonists such as (-)-MR22 are potential therapeutic drugs for the treatment of cognitive and affective disorders. To model a cognitive disorder, rats received 81-ng bilateral injections of 192- IgG-SAP (Cat. #IT-01) into the medial septum/vertical limb of the diagonal band of Broca, and 130-ng bilateral injections into the nucleus basalis magnocellularis. Lesioned animals also were treated with pre- aggregated amyloid peptide. Pretreatment with (-)-MR22 reversed cognitive impairments in the double-lesioned animals, indicating the potential use of sigma-1 receptor agonists as protective agents.
Related Products: 192-IgG-SAP (Cat. #IT-01)