Gompf HS, Mathai C, Fuller PM, Wood DA, Pedersen NP, Saper CB, Lu J (2010) Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment. J Neurosci 30(43):14543-14551. doi: 10.1523/JNEUROSCI.3037-10.2010
Objective: To examine arousal due to environmental stimuli after lesioning of the Locus ceruleus (LC).
Summary: Lesioned animals did not show sustained neurobehavioral and EEG arousal in response to a novel environment. The data suggest sustained attention requires an interaction between the LC and the anterior cingulate cortex.
Usage: Anti-DBH-SAP (0.25-1 µg) was injected into the lateral ventricle of rats.
Related Products: Anti-DBH-SAP (Cat. #IT-03)