Photochemical internalization (PCI): a technology for drug delivery.

Berg K, Weyergang A, Prasmickaite L, Bonsted A, Hogset A, Strand MT, Wagner E, Selbo PK (2010) Photochemical internalization (PCI): a technology for drug delivery. (eds. Gomer C). In: Photodynamic Therapy. Methods in Molecular Biology. 635:133-145. Humana Press, Totowa, NJ. doi: 10.1007/978-1-60761-697-9_10

Summary: This review discusses photochemical internalization (PCI), which is a method used to overcome some of the intracellular barriers to introducing molecules into cancer cells. Some difficulties for such therapies include a low rate of release from endocytic vescicles and degradation of the therapeutic molecule by lysosomal enzymes. The use of streptavidin-ZAP (Cat. #IT-27) with a biotinylated anti-EGF receptor antibody is discussed.

Related Products: Streptavidin-ZAP (Cat. #IT-27)

See Also:

• Yip WL et al. Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells. Mol Pharm 4(2):241-251, 2007.