Luo T, Leung LS (2010) Endogenous histamine facilitates long-term potentiation in the hippocampus during walking. J Neurosci 30(23):7845-7852. doi: 10.1523/JNEUROSCI.1127-10.2010
Summary: The neurotransmitter histamine is involved in several physiological functions, such as sleep-wake activites, circadian rhythms, learning, and memory. This work examines the role of histamine in modulating synaptic plasticity. Rats received 62.5 ng injections of orexin-SAP (Cat. #IT-20) into the tuberomammillary nucleus (TMN), followed by assessment of long term potentiation (LTP) during different behavioral states. The data indicate that histaminergic neurons in the TMN facilitate basal-dendritic LTP during walking.
Related Products: Orexin-B-SAP (Cat. #IT-20)