Lujan HL, Palani G, Peduzzi J, Dicarlo SE (2010) Targeted ablation of mesenteric projecting sympathetic neurons reduces the hemodynamic response to pain in conscious spinal cord transected rats. Am J Physiol Regul Integr Comp Physiol 298(5):R1358-1365. doi: 10.1152/ajpregu.00755.2009
Summary: Autonomic dysreflexia is a life-threatening hypertension as a result of a spinal cord injury above thoracic level 6. The authors investigated whether reduction of sympathetic activity can reduce the severity of this condition. Rats received 13.5 µg injections of CTB-SAP (Cat. #IT-14) into the celiac ganglion resulting in ablation of mesenteric projecting sympathetic neurons. Lesioned animals displayed a reduced pressor response to pain after spinal cord transection, to some extent ameliorating autonomic dysreflexia.
Related Products: CTB-SAP (Cat. #IT-14)